Cells must sense and process diverse stimuli in order to survive and thrive. A� Our research focuses on experimentally and theoretically answering the following questions about biological signal processing:

  • Signaling Specificity:A�How do signaling pathways that share multiple components or regulatory interactions respond specifically to their input without crosstalk? A� Under what conditions is crosstalk desirable or functional?
  • Determination ofA�in vivoA�kinetics: A�A�How fast does a signal propagate through a signaling pathway? A� How does this determine the bandwidth, or information carrying capacity, of the pathway? A� How does this signaling speed set appropriate thresholds and filtering behavior?
  • Transcription factor regulation:A�How are transcription factors regulated to produce appropriate transcriptional outputs? A� How can the dynamics of transcription factor activity be used to differentially regulate transcriptional targets? A� What is the transfer function between transcription factor concentration and transcriptional output?
  • Controllability:A�A� Given our understanding of the basic principles of biological signal processing can we control and engineer biological networks for applications in biomedicine and bioengineering?