For the most recent McClean Lab publication information see Pubmed or Google Scholar or check out recent publications in the Biomedical Engineering Department
Harmer, ZP and MN McClean (2023) Lustro: High-throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit ACS Synthetic Biology
Krause HB, Bondarowicz H, Karis AL, McClean MN and PK Kreeger (2021) Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway APL Bioengineering 5, 046101
Moreno Morales N, Patel MT, Stewart CJ, Sweeney K, and MN McClean (2021) Optogenetic tools for control of public goods in Saccharomyces cerevisiae mSphere 6(4) e00581-21
Groedem E, Sweeney, K and MN McClean (2020) Automated calibration of optoPlate LEDs to reduce light dose variation in optogenetic experiments Biotechniques doi: 10.2144/btn-2020-0077
Krishnaswamy, B and MN McClean (2020) Shining light on molecular communication in Nanocom ’20: Proceedings of the 7th ACM International Conference on Nanoscale Computing and Communication (ACM Nanocom) 11:1-7 doi/10.1145/3411295.341130
Lauterjung K, Moreno Morales N, and MN McClean (2020) Secrete to beat the heat Nature Microbiology 5:883-884
Li C, Hite Z, Warrick JW, Li J, Geller SH, Trantow VG, McClean MN* and DJ Beebe* (2020) Under oil open-channel microfluidics empowered by exclusive liquid repellency Science Advances 6(16):eaay9919 doi: 10.1126/sciadv.aay9919
An-Adirekkun J, Stewart CJ, Geller SH, Patel MT, Melendez J, Oakes BL, Noyes MB, and McClean MN (2020) A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae Biotechnol Bioeng 117(3):886-893 doi: 10.1002/bit.27234
Letourneau, A, Kegel J, Yachinich E, Al-Ramahi, J, Krause HB, Stewart CJ, and McClean MN (2020) A microfluidic device for imaging samples from microbial suspension cultures MethodsX 7:100891 doi: 10.1016/j.mex.2020.100891
Geller SH, Antwi EB, Di Ventura B, and McClean MN (2019) Optogenetic repressors of gene expression in yeasts using light-controlled nuclear localization Cellular and Molecular Bioengineering 12(5):511-528 doi: 10.1007/s12195-019-00598-9
Sweeney K, Moreno Morales N, Burmeister Z, Nimunkar A, and McClean MN (2019) Easy calibration of the Light Plate Apparatus for optogenetic experiments MethodsX 6:1480-1488 doi: 10.1016/j.mex.2019.06.008
Scott, T, Sweeney, K and MN McClean (2019) Biological signal generators: integrating synthetic biology tools and in silico control Current Opinions in Systems Biology 14:58-65
Gasch AP, Yu FB, Hose J, Escalante LE, Place M, Bacher R, Kanbar J, Ciobanu D, Sandor L, Grigoriev IV, Kendziorski C, Quake SR, McClean MN (2017) Single-cell RNA sequencing reveals instrinsic and extrinsic regulatory heterogeneity in yeast responding to stress PLOS Biology 15(12) doi:10.1371/journal.pbio.2004050
Morales NM, McClean MN (2017) Engineered bacteria self-organize to sense pressure Nature Biotechnology 35(11) 1045-1047 doi:10.1038/nbt.3992
Stewart, C. J., McClean MN (2017) Design and Implementation of an Automated Illuminating, Culturing, and Sampling System for Microbial Optogenetic Applications. Journal of Visualized Experiments(120), e54894, doi:10.3791/54894
Dexter, J.P., Xu, P., Gunawardena, J., and McClean, MN (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae BMC Systems Biology 9:17
Melendez, J., Patel, M., Oakes, B.,Xu, P., Morton, P., and McClean, MN.(2014) Real-time optogenetic control of intracellular protein concentration in microbial cell cultures Integrative Biology 6(3) 366-72
Bisaria, A., Hersen, P., and McClean, MN.(2014) Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells Methods Mol Biol. 1205111-29
Caudy, AA. et al (2013) A new system for comparative functional genomics of Saccharomyces yeasts Genetics 195(1) 275-87
Petrenko, N. Chereji, RV., McClean, MN., Morosov, AV., Broach, JR. (2013) Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses Mol Biol Cell 24(12) 2045-57
Miermont, A., Waharte, F., Hu, S., McClean, MN., Bottani, S., Leon, S., and Hersen, P. (2013) Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding Proc Natl. Acad. Sci. USA 110(14) 5725-30
McIsaac RS, Silverman SJ, Parsons, L. Xu, P., Briehof, R. McClean MN,Botstein, D. (2013) Visualization and analysis of mRNA molecules using Fluorescence in situ hybridization in budding yeast J. Vis. Exp., Jun 14;(76) JOVE Video
McIsaac RS, Silverman SJ,McClean MN, Gibney PA, Macinskas J Hickman MJ Petti AA and Botstein D (2012) Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae Mol Biol Cell 22 (22) 4447-4459
McClean, MN, Hersen, P., Ramanathan, S., (2011) Measuring in vivo signaling kinetics in a mitogen-activated protein kinase pathway using dynamic input stimulation Methods in Molecular Biology 734 101-119
Miermont, A., Uhlendorf, J., McClean, M., and Hersen, P., (2011) The Dynamical Systems Properties of the HOG Signaling Cascade Journal of Signal Transduction
McClean MN., Hersen P., Ramanathan S., (2009) In vivo measurement of signaling cascade dynamics. Cell Cycle 8 373-376
Hersen P*., McClean MN*., Mahadevan L., Ramanathan S., (2008) Signal Processing by the HOG MAP kinase pathway. Proc. Natl. Acad. Sci. USA 105 (20) 7165-7170
McClean, MN., Mody, A., Broach, J., and Ramanathan, S. (2007). Decision Making in MAP Kinase pathways. Nat. Genet. 39 (4) 409-414