For the most recent publication information see Pubmed

An-Adirekkun J, Stewart CJ, Geller SH, Patel MT, Melendez J, Oakes BL, Noyes MB, and McClean MN (2019) A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae BioRxiv (doi:

Sweeney K, Moreno Morales N, Burmeister Z, Nimunkar A, and McClean MN (2019) Easy calibration of the Light Plate Apparatus for optogenetic experiments MethodsX (In Press

Scott, T, Sweeney, K and MN McClean (2019) Biological signal generators: integrating synthetic biology tools and in silico control Current Opinions in Systems Biology 14:58-65

Gasch AP, Yu FB, Hose J, Escalante LE, Place M, Bacher R, Kanbar J, Ciobanu D, Sandor L, Grigoriev IV, Kendziorski C, Quake SR, McClean MN (2017) Single-cell RNA sequencing reveals instrinsic and extrinsic regulatory heterogeneity in yeast responding to stress PLOS Biology 15(12) doi:10.1371/journal.pbio.2004050

Morales NM, McClean MN(2017) Engineered bacteria self-organize to sense pressure Nature Biotechnology 35(11) 1045-1047 doi:10.1038/nbt.3992

Stewart, C. J., McClean MN (2017) Design and Implementation of an Automated Illuminating, Culturing, and Sampling System for Microbial Optogenetic ApplicationsJournal of Visualized Experiments(120), e54894, doi:10.3791/54894

Dexter, J.P., Xu, P., Gunawardena, J., and McClean, MN (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae BMC Systems Biology 9:17

Melendez, J., Patel, M., Oakes, B.,Xu, P., Morton, P., and McClean, MN.(2014) Real-time optogenetic control of intracellular protein concentration in microbial cell cultures Integrative Biology 6(3) 366-72

Bisaria, A., Hersen, P., and McClean, MN.(2014) Microfluidic platforms for generating dynamic environmental perturbations to study the responses of single yeast cells Methods Mol Biol. 1205111-29

Caudy, AA. et al (2013) A new system for comparative functional genomics of Saccharomyces yeasts Genetics 195(1) 275-87

Petrenko, N. Chereji, RV., McClean, MN., Morosov, AV., Broach, JR. (2013) Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses Mol Biol Cell 24(12) 2045-57

Miermont, A., Waharte, F., Hu, S., McClean, MN., Bottani, S., Leon, S., and Hersen, P. (2013) Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding Proc Natl. Acad. Sci. USA 110(14) 5725-30

McIsaac RS, Silverman SJ, Parsons, L. Xu, P., Briehof, R. McClean MN,Botstein, D. (2013) Visualization and analysis of mRNA molecules using Fluorescence in situ hybridization in budding yeast J. Vis. Exp., Jun 14;(76) JOVE Video

McIsaac RS, Silverman SJ,McClean MN, Gibney PA, Macinskas J Hickman MJ Petti AA and Botstein D (2012) Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae Mol Biol Cell 22 (22) 4447-4459

McClean, MN, Hersen, P., Ramanathan, S., (2011) Measuring in vivo signaling kinetics in a mitogen-activated protein kinase pathway using dynamic input stimulation Methods in Molecular Biology 734 101-119

Miermont, A., Uhlendorf, J., McClean, M., and Hersen, P., (2011) The Dynamical Systems Properties of the HOG Signaling Cascade Journal of Signal Transduction

McClean MN., Hersen P., Ramanathan S., (2009) In vivo measurement of signaling cascade dynamics. Cell Cycle 8 373-376

Hersen P*., McClean MN*., Mahadevan L., Ramanathan S., (2008) Signal Processing by the HOG MAP kinase pathway. Proc. Natl. Acad. Sci. USA 105 (20) 7165-7170

McClean, MN., Mody, A., Broach, J., and Ramanathan, S. (2007). Decision Making in MAP Kinase pathways. Nat. Genet. 39 (4) 409-414